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NS-1643

Catalog No.: 17030715
Cas No.: 448895-37-2
Purity : 98% 
17030715 - NS-1643 | CAS 448895-37-2

Catalog number : 17030715

CAS number : 448895-37-2

Molecular Formula : C15H10F6N2O3 

Molecular Weight : 380.2464 

Iupac Chemical Name : 1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea 

Smile : OC1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC1=C(C=CC(=C1)C(F)(F)F)O

InChiKey : NJFVQMRYJZHGME-UHFFFAOYSA-N

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SynonymsNS-1643; NS 1643; NS1643 
Molecular FormulaC15H10F6N2O3 
Molecular Weight380.2464 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileOC1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC1=C(C=CC(=C1)C(F)(F)F)O
InChiKeyNJFVQMRYJZHGME-UHFFFAOYSA-N
InChiInChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
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NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 M). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach. 

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