NS-1643
Catalog No.: 17030715
Cas No.: 448895-37-2
Purity : 98%
Catalog number : 17030715
CAS number : 448895-37-2
Molecular Formula : C15H10F6N2O3
Molecular Weight : 380.2464
Iupac Chemical Name : 1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea
Smile : OC1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC1=C(C=CC(=C1)C(F)(F)F)O
InChiKey : NJFVQMRYJZHGME-UHFFFAOYSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| Synonyms | NS-1643; NS 1643; NS1643 |
|---|---|
| Molecular Formula | C15H10F6N2O3 |
| Molecular Weight | 380.2464 |
| Appearance | off-white solid |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20ºCpowder |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| Smile | OC1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC1=C(C=CC(=C1)C(F)(F)F)O |
| InChiKey | NJFVQMRYJZHGME-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26) |
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NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 M). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.
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