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NLG919(GDC0919)

Catalog No: 52246
CAS Number: 1402836-58-1
Purity: 98% 

NLG919 is a promising and potent direct enzymatic inhibitor of IDO,In preclinical models, NLG919 showed dose dependent activation and proliferation of effector T cells, producing dramatic regression of large established tumors. Additionally, NLG919 showed enhanced immune activation and tumor regression when combined with Indoximod in this system.

Reference:
1.J Immunother Cancer. 2014; 2(Suppl 3): P250. Published online 2014 Nov 6. doi:  10.1186/2051-1426-2-S3-P250
   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292544/

 

For research use only. We do not sell to patients.

Chemical Information

NameNLG919(GDC0919)
Iupac Chemical Name1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol 
SynonymsNLG 919;NLG-919;GDC0919;RG6078. 
Molecular FormulaC18H22N2O 
Molecular Weight282.38 
SmileOC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
InChiKeyYTRRAUACYORZLX-UHFFFAOYSA-N
InChiInChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
CAS Number1402836-58-1
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

52246 - NLG919(GDC0919) | CAS 1402836-58-1

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