NLG919(GDC0919)
Catalog No: 52246
CAS Number: 1402836-58-1
Purity: 98%
NLG919 is a promising and potent direct enzymatic inhibitor of IDO,In preclinical models, NLG919 showed dose dependent activation and proliferation of effector T cells, producing dramatic regression of large established tumors. Additionally, NLG919 showed enhanced immune activation and tumor regression when combined with Indoximod in this system.
Reference:
1.J Immunother Cancer. 2014; 2(Suppl 3): P250. Published online 2014 Nov 6. doi: 10.1186/2051-1426-2-S3-P250
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292544/
For research use only. We do not sell to patients.
Chemical Information
| Name | NLG919(GDC0919) |
|---|---|
| Iupac Chemical Name | 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol |
| Synonyms | NLG 919;NLG-919;GDC0919;RG6078. |
| Molecular Formula | C18H22N2O |
| Molecular Weight | 282.38 |
| Smile | OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4 |
| InChiKey | YTRRAUACYORZLX-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2 |
| CAS Number | 1402836-58-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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