NCH-51, also known as PTACH, is a histone deacetylase (HDAC) inhibitor. NCH-51 inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 M). NCH-51 could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. NCH-51 upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA.
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