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NCH-51

Catalog No.: 17030716
Cas No.: 848354-66-5
Purity : 98% 
17030716 - NCH-51 | CAS 848354-66-5

Catalog number : 17030716

CAS number : 848354-66-5

Molecular Formula : C20H26N2O2S2 

Molecular Weight : 390.56 

Iupac Chemical Name : S-(7-oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate 

Smile : CC(C(SCCCCCCC(NC=1SC=C(N1)C1=CC=CC=C1)=O)=O)C

InChiKey : MDYDGUOQFUQOGE-UHFFFAOYSA-N

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SynonymsNCH-51; NCH 51; NCH51. PTACH 
Molecular FormulaC20H26N2O2S2 
Molecular Weight390.56 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(C(SCCCCCCC(NC=1SC=C(N1)C1=CC=CC=C1)=O)=O)C
InChiKeyMDYDGUOQFUQOGE-UHFFFAOYSA-N
InChiInChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
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NCH-51, also known as PTACH, is a histone deacetylase (HDAC) inhibitor. NCH-51 inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 M). NCH-51 could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. NCH-51 upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. 

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