NCH-51
Catalog No: 17030716
CAS Number: 848354-66-5
Purity: 98%
NCH-51, also known as PTACH, is a histone deacetylase (HDAC) inhibitor. NCH-51 inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 M). NCH-51 could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. NCH-51 upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA.
For research use only. We do not sell to patients.
Chemical Information
| Name | NCH-51 |
|---|---|
| Iupac Chemical Name | S-(7-oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate |
| Synonyms | NCH-51; NCH 51; NCH51. PTACH |
| Molecular Formula | C20H26N2O2S2 |
| Molecular Weight | 390.56 |
| Smile | CC(C(SCCCCCCC(NC=1SC=C(N1)C1=CC=CC=C1)=O)=O)C |
| InChiKey | MDYDGUOQFUQOGE-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23) |
| CAS Number | 848354-66-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
