Mutant IDH1/NAMPT-IN-1
Catalog No: 26A032
CAS Number: 3040122-14-0
Purity: ≧98.0%
Mutant IDH1/NAMPT-IN-1 ( compound 23h ) has excellent and balanced inhibitory activities against both mIDH1 (IC50 = 14.93 nM) and NAMPT (IC50 = 12.56 nM), leading to significant suppression of IDH1-mutated glioma cell (U87 MG-IDH1R132H) proliferation.
For research use only. We do not sell to patients.
Chemical Information
| Name | Mutant IDH1/NAMPT-IN-1 |
|---|---|
| Iupac Chemical Name | N-(4'-((S)-1-((4-((R)-4-((S)-1-fluoroethyl)-2-oxooxazolidin-3-yl)pyrimidin-2-yl)amino)ethyl)-[1,1'-biphenyl]-4-yl)-2-(pyridin-3-yloxy)acetamide |
| Synonyms | Mutant IDH1/NAMPT-IN-1 |
| Molecular Formula | C30H29FN6O4 |
| Molecular Weight | 556.22 |
| Smile | O=C(NC1=CC=C(C2=CC=C([C@@H](NC3=NC=CC(N4C(OC[C@@H]4[C@@H](F)C)=O)=N3)C)C=C2)C=C1)COC5=CC=CN=C5 |
| InChiKey | NGXVQQDDOXHWSX-CUVVAGTFSA-N |
| InChi | InChI=1S/C30H29FN6O4/c1-19(31)26-17-41-30(39)37(26)27-13-15-33-29(36-27)34-20(2)21-5-7-22(8-6-21)23-9-11-24(12-10-23)35-28(38)18-40-25-4-3-14-32-16-25/h3-16,19-20,26H,17-18H2,1-2H3,(H,35,38)(H,33,34,36)/t19-,20-,26+/m0/s1 |
| CAS Number | 3040122-14-0 |
| Related CAS | 3040122-14-0 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
