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Merimepodib

Catalog No.: 17030308
Cas No.: 198821-22-6
Purity : 98% 
17030308 - Merimepodib | CAS 198821-22-6

Catalog number : 17030308

CAS number : 198821-22-6

Molecular Formula : C23H24N4O6 

Molecular Weight : 452.46 

Iupac Chemical Name : (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate 

Smile : COC=1C=C(C=CC1C1=CN=CO1)NC(NC=1C=C(CNC(O[C@@H]2COCC2)=O)C=CC1)=O

InChiKey : JBPUGFODGPKTDW-SFHVURJKSA-N

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SynonymsMerimepodib; VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497 
Molecular FormulaC23H24N4O6 
Molecular Weight452.46 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCOC=1C=C(C=CC1C1=CN=CO1)NC(NC=1C=C(CNC(O[C@@H]2COCC2)=O)C=CC1)=O
InChiKeyJBPUGFODGPKTDW-SFHVURJKSA-N
InChiInChI=1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1
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Merimepodib, also known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM. In vivo, oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED(50) value of approximately 30-35 mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. These studies demonstrate that VX-497 is a potent, specific, and reversible IMPDH inhibitor that selectively inhibits lymphocyte proliferation. 

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