MT-DADMe-ImmA
Catalog No.: 703301
Cas No.: 653592-04-2
Purity : 98% by HNMR/HPLC
Catalog number : 703301
CAS number : 653592-04-2
Molecular Formula : C13H19N5OS
Molecular Weight : 293.4
Iupac Chemical Name : (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol
Smile : CSC[C@@H]1[C@@H](O)CN(CC2=CNC3=C(N)N=CN=C32)C1
InChiKey : NTHMDFGHOCNNOE-ZJUUUORDSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| Synonyms | MTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl |
|---|---|
| Molecular Formula | C13H19N5OS |
| Molecular Weight | 293.4 |
| Appearance | off-white solid |
| Purity | 98% by HNMR/HPLC |
| Solubility | Soluble in DMSO, not in water |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| Smile | CSC[C@@H]1[C@@H](O)CN(CC2=CNC3=C(N)N=CN=C32)C1 |
| InChiKey | NTHMDFGHOCNNOE-ZJUUUORDSA-N |
| InChi | InChI=1S/C13H19N5OS/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17)/t9-,10+/m1/s1 |
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Methylthio-DADMe-immucillin-A (MT-DADMe-ImmA) is an 86-pm inhibitor of human 5-methylthioadenosine phosphorylase (MTAP). Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibited MTAP, increased cellular MTA concentrations, decreased polyamines, and induced apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines.
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