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MT-DADMe-ImmA(MTDIA HCl)

Catalog No.: 712101
Cas No.: 1399840-35-7
Purity : 98% 

Methylthio-DADMe-immucillin-A (MT-DADMe-ImmA) is an 86-pm inhibitor of human 5-methylthioadenosine phosphorylase (MTAP).  Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibited MTAP, increased cellular MTA concentrations, decreased polyamines, and induced apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines.The selective action of MT-DADMe-ImmA on head and neck squamous cell carcinoma cells suggests potential as an agent for treatment of cancers sensitive to reduced CpG island methylation.

 

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Chemical Information

NameMT-DADMe-ImmA(MTDIA HCl)
Iupac Chemical Name(3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium chloride 
SynonymsMTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl 
Molecular FormulaC13H20ClN5OS 
Molecular Weight329.8 
SmileCSC[C@@H]1[C@@H](O)C[NH+](CC2=CNC3=C(N)N=CN=C32)C1.[Cl-]
InChiKeyXQKMBJFGNRIATG-UXQCFNEQSA-N
InChiInChI=1S/C13H19N5OS.ClH/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14;/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17);1H/t9-,10+;/m1./s1
CAS Number1399840-35-7
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder 
Purity98% 
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years) 
SolubilitySoluble in DMSO, not in water 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

712101 - MT-DADMe-ImmA(MTDIA HCl) | CAS 1399840-35-7

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