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MT-DADMe-ImmA(MTDIA HCl)

Catalog No.: 712101
Cas No.: 1399840-35-7
Purity : 98% 
712101 - MT-DADMe-ImmA(MTDIA HCl) | CAS 1399840-35-7

Catalog number : 712101

CAS number : 1399840-35-7

Molecular Formula : C13H20ClN5OS 

Molecular Weight : 329.8 

Iupac Chemical Name : (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium chloride 

Smile : CSC[C@@H]1[C@@H](O)C[NH+](CC2=CNC3=C(N)N=CN=C32)C1.[Cl-]

InChiKey : XQKMBJFGNRIATG-UXQCFNEQSA-N

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SynonymsMTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl 
Molecular FormulaC13H20ClN5OS 
Molecular Weight329.8 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO, not in water 
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years) 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCSC[C@@H]1[C@@H](O)C[NH+](CC2=CNC3=C(N)N=CN=C32)C1.[Cl-]
InChiKeyXQKMBJFGNRIATG-UXQCFNEQSA-N
InChiInChI=1S/C13H19N5OS.ClH/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14;/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17);1H/t9-,10+;/m1./s1
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Methylthio-DADMe-immucillin-A (MT-DADMe-ImmA) is an 86-pm inhibitor of human 5-methylthioadenosine phosphorylase (MTAP).  Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibited MTAP, increased cellular MTA concentrations, decreased polyamines, and induced apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines.The selective action of MT-DADMe-ImmA on head and neck squamous cell carcinoma cells suggests potential as an agent for treatment of cancers sensitive to reduced CpG island methylation.

 

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