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MMAF (Monomethyl auristatin F)

Catalog No.: 17030611
Cas No.: 745017-94-1
Purity : 98% 
17030611 - MMAF (Monomethyl auristatin F) | CAS 745017-94-1

Catalog number : 17030611

CAS number : 745017-94-1

Molecular Formula : C39H65N5O8 

Molecular Weight : 731.98 

Iupac Chemical Name : ((2R,3R)-3-((2S)-1-((3R,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine 

Smile : CN(C([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)C([C@@H](CC(=O)N1[C@@H](CCC1)[C@@H]([C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)C)OC)OC)[C@H](CC)C

InChiKey : MFRNYXJJRJQHNW-NARUGQRUSA-N

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SynonymsMonomethyl auristatin F; MMAF 
Molecular FormulaC39H65N5O8 
Molecular Weight731.98 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCN(C([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)C([C@@H](CC(=O)N1[C@@H](CCC1)[C@@H]([C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)C)OC)OC)[C@H](CC)C
InChiKeyMFRNYXJJRJQHNW-NARUGQRUSA-N
InChiInChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15,17-18,23-26,28-30,32-35,40H,12,16,19-22H2,1-11H3,(H,41,46)(H,42,47)(H,49,50)/t25-,26+,28-,29-,30+,32-,33-,34?,35+/m0/s1
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Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself. (https://en.wikipedia.org/wiki/Monomethyl_auristatin_F). 

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