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ML323

Catalog No.: 16122790
Cas No.: 1572414-83-5
Purity : 98% 
16122790 - ML323 | CAS 1572414-83-5

Catalog number : 16122790

CAS number : 1572414-83-5

Molecular Formula : C23H24N6 

Molecular Weight : 384.48 

Iupac Chemical Name : ML323 

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SynonymsN/A 
Molecular FormulaC23H24N6 
Molecular Weight384.48 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.ML323 inhibits the deubiquitination of PCNA and FANCD2 by inhibiting USP1CUAF1 activity in H596 cells. Moreover, ML323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA). 

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