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Catalog No.: 17022811
Cas No.: 1404437-62-2
Purity : 98% 
17022811 - ML-281 | CAS 1404437-62-2

Catalog number : 17022811

CAS number : 1404437-62-2

Molecular Formula : C22H19N3O2S 

Molecular Weight : 389.473 

Iupac Chemical Name : ML-281 

InChiKey :

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SynonymsML-281; ML-281; ML281 
Molecular FormulaC22H19N3O2S 
Molecular Weight389.473 
Appearanceoff-white solid 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers. 

1404437-62-2 - Request Bulk Quote

1404437-62-2 - Request Bulk Quote