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ML-265

Catalog No.: 17030804
Cas No.: 1221186-53-3
Purity : 98% 
17030804 - ML-265 | CAS 1221186-53-3

Catalog number : 17030804

CAS number : 1221186-53-3

Molecular Formula : C17H16N4O2S2 

Molecular Weight : 372.46 

Iupac Chemical Name : 6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 

Smile : NC=1C=C(CN2N=CC3=C(C2=O)N(C2=C3SC(=C2)S(=O)C)C)C=CC1

InChiKey : ZWKJWVSEDISQIS-UHFFFAOYSA-N

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SynonymsML265; ML-265; ML 265; CID44246499; CID-44246499; CID 44246499; NCGC00186528; NCGC 00186528; NCGC-00186528; TEPP46; TEPP 46; TEPP-46 
Molecular FormulaC17H16N4O2S2 
Molecular Weight372.46 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileNC=1C=C(CN2N=CC3=C(C2=O)N(C2=C3SC(=C2)S(=O)C)C)C=CC1
InChiKeyZWKJWVSEDISQIS-UHFFFAOYSA-N
InChiInChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
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ML265 is a potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. Cancer cells have altered metabolic processes compared to normal differentiated cells and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this aberrant metabolism. ML265 induces the more active tetrameric state of PKM2 and the X-ray co-crystal structure shows that the activator binds at the dimer-dimer interface between two subunits of PKM2. ML265 was tested in a H1299 mouse xenograft model and showed significant reduction in tumor size, weight, and occurrence with no apparent toxicity over the 7-week experiment. 

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