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ML-264

Catalog No.: 17030302
Cas No.: 1550008-55-3
Purity : 98% 
17030302 - ML-264 | CAS 1550008-55-3

Catalog number : 17030302

CAS number : 1550008-55-3

Molecular Formula : C17H21ClN2O4S 

Molecular Weight : 384.875 

Iupac Chemical Name : (E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide 

Smile : ClC=1C=C(C=CC1)/C=C/C(=O)NCC(=O)N(C)C1CCS(CC1)(=O)=O

InChiKey : AJCDZIDKYKCOMZ-AATRIKPKSA-N

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SynonymsML-264; ML264; ML 264; CID-51003603; SID 117686865, and SR-03000002171 
Molecular FormulaC17H21ClN2O4S 
Molecular Weight384.875 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileClC=1C=C(C=CC1)/C=C/C(=O)NCC(=O)N(C)C1CCS(CC1)(=O)=O
InChiKeyAJCDZIDKYKCOMZ-AATRIKPKSA-N
InChiInChI=1S/C17H21ClN2O4S/c1-20(15-7-9-25(23,24)10-8-15)17(22)12-19-16(21)6-5-13-3-2-4-14(18)11-13/h2-6,11,15H,7-10,12H2,1H3,(H,19,21)/b6-5+
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ML-264 is a Krppel-like factor 5 (KLF5) inhibitor That Potently Inhibits Growth of Colorectal Cancer. ML264 is highly active (IC50 = 29 nM is a cell-based assay for proliferation of DLD-1 cells, IC50 = 81 nM in a cell-based luciferase assay). It lacks cytotoxicity in the IEC-6 control cell line (IC50 >50 M, <50% inhibition was observed at 100 M). Robust activity was also seen in several other KLF5-expressing cell types as well (e.g., HCT116, IC50 = 560 nM; HT29, IC50 = 130 nM; SW620, IC50 = 430 nM). ML264 is a good candidate for in vivo anticancer studies, with great potential for use in long time-course in situ studies aimed to elucidate the role of KLF5 as a regulator of cellular proliferation and tumor formation in the intestinal epithelium. 

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