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MK-8245

Catalog No.: 17030109
Cas No.: 1030612-90-8
Purity : 98% 
17030109 - MK-8245 | CAS 1030612-90-8

Catalog number : 17030109

CAS number : 1030612-90-8

Molecular Formula : C15H14BrFN6O2 

Molecular Weight : 409.21306 

Iupac Chemical Name : MK-8245 

Smile : c1cc(c(cc1F)OC2CCN(CC2)c3cc(on3)c4nnn(n4)CC(=O)O)Br

InChiKey : UJEAABFSXKCSGI-UHFFFAOYSA-N

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SynonymsMK-8245; MK8245; MK8245 
Molecular FormulaC15H14BrFN6O2 
Molecular Weight409.21306 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(c(cc1F)OC2CCN(CC2)c3cc(on3)c4nnn(n4)CC(=O)O)Br
InChiKeyUJEAABFSXKCSGI-UHFFFAOYSA-N
InChiInChI=1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
MDLMFCD20039622
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MK-8245 is a potent, liver-targeted SCD inhibitor with preclinical antidiabetic and antidyslipidemic efficacy with a significantly improved therapeutic window. MK-8245 was believed to inhibit the SCD enzyme solely in the liver and not in other tissues for the following reasons. When SCD inhibition has been measured by desaturation index in tissues of rodents treated with MK-8245, the desaturation index was significantly reduced in liver but not in other tissues such as skin, eye and adipose tissue. 

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