MI-503
Catalog No: 178908
CAS Number: 1857417-13-0
Purity: 98.0%
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range).
For research use only. We do not sell to patients.
Chemical Information
| Name | MI-503 |
|---|---|
| Iupac Chemical Name | 4-Methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile |
| Synonyms | MI503 |
| Molecular Formula | C28H27F3N8S |
| Molecular Weight | 564.64 |
| Smile | CC1=C2C=C(N(C2=CC=C1CN1CCC(CC1)NC=1C2=C(N=CN1)SC(=C2)CC(F)(F)F)CC=2C=NNC2)C#N |
| InChiKey | DETOMBLLEOZTMZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H27F3N8S/c1-17-19(2-3-25-23(17)8-21(11-32)39(25)14-18-12-35-36-13-18)15-38-6-4-20(5-7-38)37-26-24-9-22(10-28(29,30)31)40-27(24)34-16-33-26/h2-3,8-9,12-13,16,20H,4-7,10,14-15H2,1H3,(H,35,36)(H,33,34,37) |
| CAS Number | 1857417-13-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98.0% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
