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MI-2 (MALT1 inhibitor)

Catalog No: 16123047
CAS Number: 1047953-91-2
Purity: 98% 

MI-2 is a MALT1 inhibitor (IC50 = 5.84 M). MI-2 binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-B activity induced by MALT1. Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), a paracaspase and essential regulator for nuclear factor kB (NF-B) activation, plays an important role in innate and adaptive immunity. Suppression of MALT1 protease activity with small molecule inhibitors showed promising efficacies in subtypes of B cell lymphoma and improvement in experimental autoimmune encephalomyelitis model. 

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Chemical Information

NameMI-2 (MALT1 inhibitor)
Iupac Chemical NameMI-2 (MALT1 inhibitor) 
SynonymsMI 2; MI2 
Molecular FormulaC19H17Cl3N4O3 
Molecular Weight455.72 
InChiKey
InChi
CAS Number1047953-91-2
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16123047 - MI-2 (MALT1 inhibitor) | CAS 1047953-91-2

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