MA242 TFA
Catalog No: 25206
CAS Number: 1049704-18-8
Purity: ≧98.0%
MA242 is MDM2 and NFAT1 dual inhibitor that induces MDM2 auto-ubiquitination and degradation and represses NFAT1-mediated MDM2 transcription. MA242 profoundly inhibits the growth and metastasis of HCC cells in vitro and in vivo, independent of p53.
For research use only. We do not sell to patients.
Chemical Information
| Name | MA242 TFA |
|---|---|
| Iupac Chemical Name | 7-((4-chlorobenzyl)amino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one 2,2,2-trifluoroacetate |
| Synonyms | MA242 TFA ; MA242 ; MA-242 ; MA 242 ; |
| Molecular Formula | C26H21ClF3N3O5S |
| Molecular Weight | 579.08 |
| Smile | O=C1C2=C3C(CCN=C3C=C1NCC4=CC=C(C=C4)Cl)=CN2S(=O)(C5=CC=C(C=C5)C)=O.O=C(C(F)(F)F)O |
| InChiKey | YTSFRIUMZUCDMV-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H20ClN3O3S.C2HF3O2/c1-15-2-8-19(9-3-15)32(30,31)28-14-17-10-11-26-20-12-21(24(29)23(28)22(17)20)27-13-16-4-6-18(25)7-5-16;3-2(4,5)1(6)7/h2-9,12,14,27H,10-11,13H2,1H3;(H,6,7) |
| CAS Number | 1049704-18-8 |
| Related CAS | 1049704-17-7 (free base) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | MDM2 and NFAT1 dual inhibitor |
|---|---|
| Mechanism | MA242 is MDM2 and NFAT1 dual inhibitor that induces MDM2 auto-ubiquitination and degradation and represses NFAT1-mediated MDM2 transcription. MA242 profoundly inhibits the growth and metastasis of HCC cells in vitro and in vivo, independent of p53. |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
