Lonafarnib
Catalog No: 16071008
CAS Number: 193275-84-2
Purity: 98% by HPLC
Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Check for active clinical trials or closed clinical trials using this agent.
For research use only. We do not sell to patients.
Chemical Information
| Name | Lonafarnib |
|---|---|
| Iupac Chemical Name | 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide |
| Synonyms | US brand name: Sarasar |
| Molecular Formula | C27H31Br2ClN4O2 |
| Molecular Weight | 638.82 |
| Smile | ClC=1C=C(C2=C(CCC=3C(=NC=C(C3)Br)C2C2CCN(CC2)C(CC2CCN(CC2)C(=O)N)=O)C1)Br |
| InChiKey | DHMTURDWPRKSOA-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36) |
| CAS Number | 193275-84-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
