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Lomitapide free base

Catalog No.: 16123035
Cas No.: 182431-12-5
Purity : 98% 

Lomitapide is a MTP inhibitor. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH. 

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Chemical Information

NameLomitapide free base
Iupac Chemical NameLomitapide free base 
SynonymsAEGR 733; AEGR733; AEGR-733; BMS 201038; BMS-201038; BMS201038; BMS 201038-01. Lomitapide mesylate. Brand name: Juxtapid; Lojuxta. 
Molecular FormulaC39H37F6N3O2 
Molecular Weight693.73442 
Smilec1ccc(c(c1)c2ccc(cc2)C(F)(F)F)C(=O)NC3CCN(CC3)CCCCC4(c5ccccc5-c6c4cccc6)C(=O)NCC(F)(F)F
InChiKeyMBBCVAKAJPKAKM-UHFFFAOYSA-N
InChiInChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
CAS Number182431-12-5
MDLMFCD16620494
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16123035 - Lomitapide free base | CAS 182431-12-5

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