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Lerociclib HCl (G1T38 HCl)

Catalog No.: 2073106
Cas No.: 2097938-59-3
Purity : ≧98.0%

Lerociclib HCl (G1T38) is a novel, selective,differentiated oral CDK4/6 inhibitor with biochemical IC50 values of 1 nM, 2 nM and 28 μnM for CDK4, CDK6 and CDK9 respectively. Lerociclib (G1T38) with potential use in combination with other targeted therapies in certain types of breast and lung cancer.

Lerociclib (Free base) , Bulk in stock, contact us by email for the Bulk quotation.

For research use only. We do not sell to patients.

Chemical Information

NameLerociclib HCl (G1T38 HCl)
Iupac Chemical Name2'-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride
SynonymsLerociclib HCl ; G1T38 dihydrochloride ; G1T 38 dihydrochloride
Molecular FormulaC26H36Cl2N8O
Molecular Weight547.52
SmileO=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C(C)C)CC6)C=C5)N=C43)CCCCC2.[H]Cl.[H]Cl
InChiKeyIUIVDLVJNPANBY-UHFFFAOYSA-N
InChiInChI=1S/C26H34N8O.2ClH/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25;;/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31);2*1H
CAS Number2097938-59-3
Related CAS2097938-59-3 (HCl) ;1628256-23-4 (free base)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
Formulationlight-yellow solid to off-white solid 
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature 
HS Code2933999701
Coming soon.
TargetsCDK4/6 inhibitor
MechanismLerociclib (G1T38 ) is a novel, selective,differentiated oral CDK4/6 inhibitor with biochemical IC50 values of 1 nM, 2 nM and 28 μnM for CDK4, CDK6 and CDK9 respectively. Lerociclib (G1T38) with potential use in combination with other targeted therapies in certain types of breast and lung cancer.
Cell study
Animal study
Clinical study
Not available

Chemical Structure

2073106 - Lerociclib HCl (G1T38 HCl) | CAS 2097938-59-3

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