Ladarixin (DF-2156 ; DF-2156A) is an orally active, allosteric non-competitive and dual CXCR1and CXCR2 antagonist.
For research use only. We do not sell to patients.
| Name | Ladarixin |
|---|---|
| Iupac Chemical Name | (R)-4-(1-(methylsulfonamido)-1-oxopropan-2-yl)phenyl trifluoromethanesulfonate |
| Synonyms | DF-2156 ; DF-2156A ; DF2156 ; DF2156A ; DF 2156 ; DF 2156A ; Ladarixin |
| Molecular Formula | C11H12F3NO6S2 |
| Molecular Weight | 375.34 |
| Smile | O=S(OC1=CC=C([C@@H](C)C(NS(=O)(C)=O)=O)C=C1)(C(F)(F)F)=O |
| InChiKey | DDLPYOCJHQSVSZ-SSDOTTSWSA-N |
| InChi | InChI=1S/C11H12F3NO6S2/c1-7(10(16)15-22(2,17)18)8-3-5-9(6-4-8)21-23(19,20)11(12,13)14/h3-7H,1-2H3,(H,15,16)/t7-/m1/s1 |
| CAS Number | 849776-05-2 |
| Related CAS | 849776-05-2 |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
| Targets | CXCR antagonist |
|---|---|
| Mechanism | Chemokine CXCR1/CXCR2 (IL-8 Receptor) Receptor Antagonists ; Chemokine CXCR1 (IL-8 alpha Receptor) Antagonists ; Chemokine CXCR2 (IL-8 beta Receptor) Antagonists |
| Cell study | Signal Transduction Modulators |
| Animal study | |
| Clinical study | Phase III |