Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

LY2109761

Catalog No: 16123039
CAS Number: 700874-71-1
Purity: 98% 

LY2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor. The effect of LY2109761 has been evaluated on soft agar growth, migration, invasion using a fibroblast coculture model, and detachment-induced apoptosis (anoikis) by Annexin V flow cytometric analysis. The efficacy of LY2109761 on tumor growth, survival, and reduction of spontaneous metastasis have been evaluated in an orthotopic murine model of metastatic pancreatic cancer expressing both luciferase and green fluorescence proteins (L3.6pl/GLT). In vivo, LY2109761 , in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. 

For research use only. We do not sell to patients.

Chemical Information

NameLY2109761
Iupac Chemical NameLY2109761 
SynonymsLY 2109761; LY-2109761 
Molecular FormulaC26H27N5O2 
Molecular Weight441.52 
Smilec1ccnc(c1)c2c(c3n(n2)CCC3)c4ccnc5c4ccc(c5)OCCN6CCOCC6
InChiKeyIHLVSLOZUHKNMQ-UHFFFAOYSA-N
InChiInChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
CAS Number700874-71-1
MDLMFCD12923354
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16123039 - LY2109761 | CAS 700874-71-1

Quick Order

Change