LXH-3-71
Catalog No: 24107
CAS Number: 2251753-65-6
Purity: ≧97.0%
LXH-3-71 is novel "molecular glue" that induces the interaction between PHGDH and DDB1-CUL4 ubiquitin ligase, triggering degradation of PHGDH via the ubiquitination proteasome pathway and subsequently leading to inhibited cancer cell stemness.
For research use only. We do not sell to patients.
Chemical Information
| Name | LXH-3-71 |
|---|---|
| Iupac Chemical Name | (4aS,6aS,6bR,8aR,12aR,12bR,14bS)-N-(2-(3-(4-methoxyphenyl)ureido)ethyl)-2,2,6a,6b,9,9,12a-heptamethyl-11-methylene-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxamide |
| Synonyms | LXH-3-71 |
| Molecular Formula | C41H59N3O4 |
| Molecular Weight | 657.94 |
| Smile | O=C([C@]1(CC[C@@]2(C)[C@]3(C)CC[C@@]4([H])C(C)(C)C5=O)CCC(C)(C)C[C@@]1([H])C2=CC[C@]3([H])[C@@]4(C)CC5=C)NCCNC(NC6=CC=C(OC)C=C6)=O |
| InChiKey | KHAFPBAKIVPZNQ-RRBGEOAMSA-N |
| InChi | InChI=1S/C41H59N3O4/c1-26-24-38(6)31(37(4,5)33(26)45)16-17-40(8)32(38)15-14-29-30-25-36(2,3)18-20-41(30,21-19-39(29,40)7)34(46)42-22-23-43-35(47)44-27-10-12-28(48-9)13-11-27/h10-14,30-32H,1,15-25H2,2-9H3,(H,42,46)(H2,43,44,47)/t30-,31-,32+,38-,39+,40+,41-/m0/s1 |
| CAS Number | 2251753-65-6 |
| Related CAS | 2251753-65-6 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | ≧97.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
