LX1606 (Hippurate)
编号: 16062301
Cas号: 1137608-69-5
纯度: 98% by HPLC
LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. IC50 Value: Target: Tryptophan hydroxylase in vitro: in vivo: LX1606 (LX 1606, LX-1606) is useful for Neurological Diseas [1]. LX1606 were given orally to mice. LX1606 reduced 5-HT significantly in the gut and blood but not in the brain. oral LX1032 reduced the severity of TNBS-induced colitis; the expression of 24% of 84 genes encoding inflammation-related cytokines and chemokines was lowered at least fourfold and the reduced expression of 17% was statistically significant [1]. Treatment with LX1606 showed a strong positive effect in ameliorating TNBS-induced IBD in mice as assessed by various parameters of disease development. These preclinical data demonstrate that inhibition of TPH activity by LX1606 may provide a new approach for the treatment of IBD and its serotonin-mediated symptoms[3].
For research use only. We do not sell to patients.
化学信息
| 名称 | LX1606 (Hippurate) |
|---|---|
| Iupac 化学名称 | 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt |
| 同义词 | LX1606 hippurate |
| 分子式 | C36H35ClF3N7O6 |
| 分子量 | 754.15 |
| Smile | C(C1=CC=CC=C1)(=O)NCC(=O)O.C(C)OC([C@@H](N)CC1=CC=C(C=C1)C1=NC(=NC(=C1)O[C@@H](C(F)(F)F)C1=C(C=C(C=C1)Cl)N1N=C(C=C1)C)N)=O |
| InChiKey | XSFPZBUIBYMVEA-CELUQASASA-N |
| InChi | InChI=1S/C27H26ClF3N6O3.C9H9NO3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37;11-8(12)6-10-9(13)7-4-2-1-3-5-7/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35);1-5H,6H2,(H,10,13)(H,11,12)/t20-,24+;/m0./s1 |
| Cas号 | 1137608-69-5 |
| Related CAS |
订购信息
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