LSN2463359
LSN2463359 is a novel positive allosteric modulators of the mGlu₅ receptor.
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Chemical Information
| Name | LSN2463359 |
|---|---|
| Iupac Chemical Name | N-(propan-2-yl)-5-[2-(pyridin-4-yl)ethynyl]pyridine-2-carboxamide |
| Synonyms | LSN2463359; LSN-2463359; LSN 2463359. |
| Molecular Formula | C16H15N3O |
| Molecular Weight | 265.31 |
| Smile | O=C(C1=NC=C(C#CC2=CC=NC=C2)C=C1)NC(C)C |
| InChiKey | STAFRSGTRKNXHF-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20) |
| CAS Number | 1401031-52-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Purity | 98% Min. |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, Tricklebank MD. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. doi: 10.1016/j.neuropharm.2012.07.030. PubMed PMID: 22884720.
2: Gastambide F, Gilmour G, Robbins TW, Tricklebank MD. The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat. Neuropharmacology. 2013 Jan;64:240-7. doi: 10.1016/j.neuropharm.2012.07.039. PubMed PMID: 22884612.
3: Gastambide F, Cotel MC, Gilmour G, O'Neill MJ, Robbins TW, Tricklebank MD. Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator. Neuropsychopharmacology. 2012 Mar;37(4):1057-66. doi: 10.1038/npp.2011.298. PubMed PMID: 22129780; PubMed Central PMCID: PMC3280638.
Chemical Structure
