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LOXO-292

Catalog No.: 192195
Cas No.: 2222755-14-6
Purity : >98%
192195 - LOXO-292 | CAS 2222755-14-6

Catalog number : 192195

CAS number : 2222755-14-6

Molecular Formula : C29H31N9O3

Molecular Weight : 553.627

Iupac Chemical Name : 4-(5-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyrazin-2-yl)-6-(((R)-morpholin-2-yl)methoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

Smile : N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1

InChiKey : GTQISTQEBXXLPC-UBVWURDFSA-N

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SynonymsLOXO-292; LOXO292; LOXO 292; ARRY-192; ARRY192; ARRY 192
Molecular FormulaC29H31N9O3
Molecular Weight553.627
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileN#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1
InChiKeyGTQISTQEBXXLPC-UBVWURDFSA-N
InChiInChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1
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LOXO-292 (ARRY-192) is an oral and selective investigational drug in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase.

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