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LOXO-101 (ARRY-470)

Catalog No.: 16123036
Cas No.: 1223403-58-4
Purity : 98%

Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB,

For research use only. We do not sell to patients.

Chemical Information

NameLOXO-101 (ARRY-470)
Iupac Chemical Name(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
SynonymsLOXO101;ARRY-470;ARRY470;ARRY 470;larotrectinib
Molecular FormulaC21H22F2N6O2
Molecular Weight428.44
SmileFC1=C(C=C(C=C1)F)[C@@H]1N(CCC1)C1=NC=2N(C=C1)N=CC2NC(=O)N2C[C@H](CC2)O
InChiKeyNYNZQNWKBKUAII-KBXCAEBGSA-N
InChiInChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
CAS Number1223403-58-4
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid
Purity98%
Storage3 years -20℃powder
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16123036 - LOXO-101 (ARRY-470) | CAS 1223403-58-4

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