Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

L755507

Catalog No: 16122732
CAS Number: 159182-43-1
Purity: 98% 

L-755,507 is characterized as a potent and selective 3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.L-755,507 displays an excellent activity profile as an extremely potent human 3 adrenergic receptor agonist (3 EC50 0.43 nM), with >440-fold selectivity over 1 and 2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human 3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold. 

For research use only. We do not sell to patients.

Chemical Information

NameL755507
Iupac Chemical NameL755507 
SynonymsN/A 
Molecular FormulaC30H40N4O6S 
Molecular Weight584.73 
SmileCCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)CCNC[C@@H](COc3ccc(cc3)O)O
InChiKeyNYYJKMXNVNFOFQ-MHZLTWQESA-N
InChiInChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
CAS Number159182-43-1
MDLMFCD08703099
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122732 - L755507 | CAS 159182-43-1

Quick Order

Change