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Ko 143

Catalog No.: 111908
Cas No.: 461054-93-3
Purity : 98% 
111908 - Ko 143 | CAS 461054-93-3

Catalog number : 111908

CAS number : 461054-93-3

Molecular Formula : C26H35N3O5 

Molecular Weight : 469.573 

Iupac Chemical Name : (3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester 

Smile : CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

InChiKey : NXNRAECHCJZNRF-UHFFFAOYSA-N

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SynonymsKo-143; Ko143 
Molecular FormulaC26H35N3O5 
Molecular Weight469.573 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
InChiKeyNXNRAECHCJZNRF-UHFFFAOYSA-N
InChiInChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)
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Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters. 

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