KT-474 ( Synonyms: SAR-444656 )
Catalog No: 25165
CAS Number: 2432994-31-3
Purity: ≧98.0%
KT-474 (SAR-444656) is an orally available IRAK4 degradation inducer.
For research use only. We do not sell to patients.
Chemical Information
| Name | KT-474 ( Synonyms: SAR-444656 ) |
|---|---|
| Iupac Chemical Name | N-[3-(Difluoromethyl)-1-[(trans)-4-[[4-([3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl]prop-2-yn-1-yl]oxy)piperidin-1-yl]methyl]cyclohexyl]-1H-pyrazol-4-yl]-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Synonyms | SAR-444656 ; SAR444656 ; SAR 444656 ; KT-474 ; KT474 ; KT 474 |
| Molecular Formula | C44H49F2N11O6 |
| Molecular Weight | 865.94 |
| Smile | O=C(C1=C2N=C(N3[C@@]4([H])CO[C@@](C4)([H])C3)C=CN2N=C1)NC5=CN([C@H]6CC[C@H](CN7CCC(OCC#CC8=C(C(N9C(CC%10)C(NC%10=O)=O)=CC=C8)N(C)C9=O)CC7)CC6)N=C5C(F)F |
| InChiKey | NQGKNAVUMAHSQN-KDRPOVOJSA-N |
| InChi | InChI=1S/C44H49F2N11O6/c1-52-39-27(4-2-6-34(39)57(44(52)61)35-11-12-37(58)50-43(35)60)5-3-19-62-30-13-16-53(17-14-30)22-26-7-9-28(10-8-26)56-24-33(38(51-56)40(45)46)48-42(59)32-21-47-55-18-15-36(49-41(32)55)54-23-31-20-29(54)25-63-31/h2,4,6,15,18,21,24,26,28-31,35,40H,7-14,16-17,19-20,22-23,25H2,1H3,(H,48,59)(H,50,58,60)/t26-,28-,29-,31-,35?/m1/s1 |
| CAS Number | 2432994-31-3 |
| Related CAS | 2432994-31-3 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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