KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 M in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
For research use only. We do not sell to patients.
| Name | KS176 |
|---|---|
| Iupac Chemical Name | N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide |
| Synonyms | KS 176; KS-176 |
| Molecular Formula | C22H19N3O5 |
| Molecular Weight | 405.4 |
| Smile | OCCC1=CC=C(C=C1)NC(C1=C(C=CC=C1)NC(C1=CC=C(C=C1)[N+](=O)[O-])=O)=O |
| InChiKey | LTWQQWSXYYXVGA-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27) |
| CAS Number | 1253452-78-6 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |