KH-CB19
Catalog No: 611922
CAS Number: 1354037-26-5
Purity: 98%
KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF--induced increase in phosphorylation of all analyzed SR proteins compared with TNF--stimulated controls.Treatment of resting cells with 10 M KH-CB19 significantly reduced the basal expression of flTF as well as asHTF.
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Chemical Information
| Name | KH-CB19 |
|---|---|
| Iupac Chemical Name | KH-CB19 |
| Synonyms | KH-CB-19 |
| Molecular Formula | C15H13Cl2N3O2 |
| Molecular Weight | 338.19 |
| InChiKey | |
| InChi | |
| CAS Number | 1354037-26-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
