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KGP-94

Catalog No: 3291806
CAS Number: 1131456-28-4
Purity: >98%

KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. ► KGP94 inhibits the activity of cathepsin L toward human type I collagen. ► KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. ► Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. ► Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment.

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Chemical Information

NameKGP-94
Iupac Chemical Name2-((3-bromophenyl)(3-hydroxyphenyl)methylene)hydrazinecarbothioamide
SynonymsKGP-94;KGP94;KGP 94
Molecular FormulaC14H12BrN3OS
Molecular Weight350.23
SmileOC1=CC(/C(C2=CC=CC(Br)=C2)=N\NC(N)=S)=CC=C1
InChiKeyZDBKSZKTCPOBFR-LGMDPLHJSA-N
InChiInChI=1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)/b17-13-
CAS Number1131456-28-4
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Ordering Information

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Formulationoff-white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO, acetone, not in water
Handling
Shipping ConditionShipped under ambient temperature
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

3291806 - KGP-94 | CAS 1131456-28-4

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