KB-R7943 mesylate
Catalog No: 16122826
CAS Number: 182004-65-5
Purity: 98%
KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 M). KB-R7943 does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. KB-R7943 blocks opening of the mitochondrial permeability transition pore. KB-R7943 restores endothelium-dependent relaxation induced by advanced glycosylation end products in rat aorta. KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.
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Chemical Information
| Name | KB-R7943 mesylate |
|---|---|
| Iupac Chemical Name | KB-R7943 mesylate |
| Synonyms | KB-R7943; KB R7943; KB-R 7943 |
| Molecular Formula | C17H21N3O6S2 |
| Molecular Weight | 427.49 |
| Smile | CS(=O)(=O)O.c1cc(ccc1CCSC(=N)N)OCc2ccc(cc2)[N+](=O)[O-] |
| InChiKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) |
| CAS Number | 182004-65-5 |
| MDL | MFCD00952138 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
