JWH 133 is a potent CB2 selective agonist with Ki of 3.4 nM, 200-fold selective over CB1 receptors.
JWH-133 inhibits IL-12p40 production and enhances IL-10 release by activated macrophages through a CB2 receptor-mediated pathway. a widely used experimental in vitro model to study mechanisms of toxicity and protection in nigral dopaminergic neurons. JWH-133 (10-40 M) induced a concentration-dependent decrease of SH-SY5Y cell viability and proliferation rate.
For research use only. We do not sell to patients.