JNJ-632
JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. Administration of JNJ-632 in HBV genotype D infected chimeric mice, resulted in a 2.77 log reduction of the HBV DNA viral load.
For research use only. We do not sell to patients.
Chemical Information
| Name | JNJ-632 |
|---|---|
| Iupac Chemical Name | (S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide |
| Synonyms | JNJ-632; JNJ 632; JNJ632. |
| Molecular Formula | C18H19FN2O4S |
| Molecular Weight | 378.4184 |
| Smile | O=C(NC1=CC=C(F)C(C)=C1)C2=CC=CC(S(=O)(N[C@@H]3COCC3)=O)=C2 |
| InChiKey | JIZGLOVJKCSHTH-HNNXBMFYSA-N |
| InChi | InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1 |
| CAS Number | 1572510-42-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J,
Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson PJMB. Synthesis and
Evaluation of N-phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly
Modulators inhibiting Hepatitis B Virus (HBV). J Med Chem. 2018 Jun 15. doi:
10.1021/acs.jmedchem.8b00654. [Epub ahead of print] PubMed PMID: 29906396.
2: Berke JM, Dehertogh P, Vergauwen K, Van Damme E, Mostmans W, Vandyck K,
Pauwels F. Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary
Human Hepatocytes Infected with Hepatitis B Virus. Antimicrob Agents Chemother.
2017 Jul 25;61(8). pii: e00560-17. doi: 10.1128/AAC.00560-17. Print 2017 Aug.
PubMed PMID: 28584155; PubMed Central PMCID: PMC5527576.
Chemical Structure
