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JH-VIII-157-02

Catalog No.: 62103
Cas No.: 1639422-97-1
Purity : 98% by HPLC 
62103 - JH-VIII-157-02 | CAS 1639422-97-1

Catalog number : 62103

CAS number : 1639422-97-1

Molecular Formula : C28H27N5O2 

Molecular Weight : 465.55 

Iupac Chemical Name : 1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl- 

Smile : O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1

InChiKey : IDGNCVHQDDOPND-UHFFFAOYSA-N

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SynonymsJH-VIII-157-02;CAS#1639422-97-1 
Molecular FormulaC28H27N5O2 
Molecular Weight465.55 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileO=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1
InChiKeyIDGNCVHQDDOPND-UHFFFAOYSA-N
InChiInChI=1S/C28H27N5O2/c1-6-17-10-21-22(11-20(17)18-13-30-33(14-18)15-24(34)32(4)5)28(2,3)27-25(26(21)35)19-8-7-16(12-29)9-23(19)31-27/h7-11,13-14,31H,6,15H2,1-5H3
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JH-VIII-157-02, a structural analogue of alectinib, is potent against the G1202R mutant as well as a variety of other frequently observed mutants. In addition, it is capable of penetrating the CNS of mice following oral dosing. 

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