JC124
Catalog No: 20495
CAS Number: 1638611-48-9
Purity: 98% Min.
JC124 is a NLRP3 Inflammasome Inhibitor.
For research use only. We do not sell to patients.
Chemical Information
| Name | JC124 |
|---|---|
| Iupac Chemical Name | 5-chloro-2-methoxy-N-(4-(N-methylsulfamoyl)phenethyl)benzamide |
| Synonyms | JC124; JC-124; JC 124; |
| Molecular Formula | C17H19ClN2O4S |
| Molecular Weight | 382.86 |
| Smile | O=C(NCCC1=CC=C(S(=O)(NC)=O)C=C1)C2=CC(Cl)=CC=C2OC |
| InChiKey | LXYPQRJNQPYTQW-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H19ClN2O4S/c1-19-25(22,23)14-6-3-12(4-7-14)9-10-20-17(21)15-11-13(18)5-8-16(15)24-2/h3-8,11,19H,9-10H2,1-2H3,(H,20,21) |
| CAS Number | 1638611-48-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Fulp J, He L, Toldo S, Jiang Y, Boice A, Guo C, Li X, Rolfe A, Sun D, Abbate A, Wang XY, Zhang S. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00733. [Epub ahead of print] PubMed PMID: 29877709.
2. 1: Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2018 Mar;55(3):1977-1987. doi: 10.1007/s12035-017-0467-9. Epub 2017 Mar 2. PubMed PMID: 28255908; PubMed Central PMCID: PMC5585057.
Chemical Structure
