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Ilomastat

Catalog No: 16070104
CAS Number: 142880-36-2
Purity: 98% by HPLC 

Ilomastat, also known as GM6001 and galardin, is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity. GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Examples of enzymes that ilomastat inhibit include thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. 

For research use only. We do not sell to patients.

Chemical Information

NameIlomastat
Iupac Chemical Name(R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide 
SynonymsGM6001 ; GM-6001 
Molecular FormulaC20H28N4O4 
Molecular Weight388.46072 
SmileN1C=C(C2=CC=CC=C12)C[C@@H](C(=O)NC)NC([C@@H](CC(=O)NO)CC(C)C)=O
InChiKeyNITYDPDXAAFEIT-DYVFJYSZSA-N
InChiInChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
CAS Number142880-36-2
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16070104 - Ilomastat | CAS 142880-36-2

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