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Idasanutlin (RG7388)

Catalog No.: 16070812
Cas No.: 1229705-06-9
Purity : 98% by HPLC 
16070812 - Idasanutlin (RG7388) | CAS 1229705-06-9

Catalog number : 16070812

CAS number : 1229705-06-9

Molecular Formula : C31H29Cl2F2N3O4 

Molecular Weight : 616.48247 

Iupac Chemical Name : 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid. 

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SynonymsRG7388; RG 7388 
Molecular FormulaC31H29Cl2F2N3O4 
Molecular Weight616.48247 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
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Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. 

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