Idalopirdine (Lu AE58054)
Catalog No: 16122821
CAS Number: 467459-31-0
Purity: 98%
Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease.
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Chemical Information
| Name | Idalopirdine (Lu AE58054) |
|---|---|
| Iupac Chemical Name | Idalopirdine (Lu AE58054) |
| Synonyms | Lu AE58054; Lu AE-58054; Lu AE 58054; Idalopirdine; Iladopirdine |
| Molecular Formula | C20H19F5N2O |
| Molecular Weight | 398.377 |
| Smile | c1cc(cc(c1)OCC(C(F)F)(F)F)CNCCc2c[nH]c3c2ccc(c3)F |
| InChiKey | YBAWYTYNMZWMMJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2 |
| CAS Number | 467459-31-0 |
| MDL | MFCD18633269 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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