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Idalopirdine (Lu AE58054)

Catalog No.: 16122821
Cas No.: 467459-31-0
Purity : 98% 
16122821 - Idalopirdine (Lu AE58054) | CAS 467459-31-0

Catalog number : 16122821

CAS number : 467459-31-0

Molecular Formula : C20H19F5N2O 

Molecular Weight : 398.377 

Iupac Chemical Name : Idalopirdine (Lu AE58054) 

Smile : c1cc(cc(c1)OCC(C(F)F)(F)F)CNCCc2c[nH]c3c2ccc(c3)F

InChiKey : YBAWYTYNMZWMMJ-UHFFFAOYSA-N

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SynonymsLu AE58054; Lu AE-58054; Lu AE 58054; Idalopirdine; Iladopirdine 
Molecular FormulaC20H19F5N2O 
Molecular Weight398.377 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(cc(c1)OCC(C(F)F)(F)F)CNCCc2c[nH]c3c2ccc(c3)F
InChiKeyYBAWYTYNMZWMMJ-UHFFFAOYSA-N
InChiInChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2
MDLMFCD18633269
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Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease. 

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