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IU1

Catalog No.: 51637
Cas No.: 314245-33-5
Purity : 98% 
51637 - IU1 | CAS 314245-33-5

Catalog number : 51637

CAS number : 314245-33-5

Molecular Formula : C18H21FN2O 

Molecular Weight : 300.37 

Iupac Chemical Name : 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone 

Smile : CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

InChiKey : JUWDSDKJBMFLHE-UHFFFAOYSA-N

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SynonymsIU1 
Molecular FormulaC18H21FN2O 
Molecular Weight300.37 
Appearancelight yellow solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature. 
SmileCC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
InChiKeyJUWDSDKJBMFLHE-UHFFFAOYSA-N
InChiInChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
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IU1 is a reversible and specific inhibitor of proteasome-associating Usp14. It does not inhibit other deubiquitinating enzymes of the 26S proteasome. It partially inhibits the ubiquitin chain trimming activity of the 26S proteasome, which could function to stimulate the degradation of some proteasomal substrates.

 

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