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IPI-549(IPI549)

Catalog No.: 711401
Cas No.: 1693758-51-8
Purity : 98% 
711401 - IPI-549(IPI549) | CAS 1693758-51-8

Catalog number : 711401

CAS number : 1693758-51-8

Molecular Formula : C30H24N8O2 

Molecular Weight : 528.576 

Iupac Chemical Name : (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 

Smile : O=C(C1=C2N=CC=CN2N=C1N)N[C@H](C3=CC4=C(C(N3C5=CC=CC=C5)=O)C(C#CC6=CN(C)N=C6)=CC=C4)C

InChiKey : XUMALORDVCFWKV-IBGZPJMESA-N

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SynonymsIPI-549; IPI 549; IPI549 
Molecular FormulaC30H24N8O2 
Molecular Weight528.576 
Appearancelight-yellow solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileO=C(C1=C2N=CC=CN2N=C1N)N[C@H](C3=CC4=C(C(N3C5=CC=CC=C5)=O)C(C#CC6=CN(C)N=C6)=CC=C4)C
InChiKeyXUMALORDVCFWKV-IBGZPJMESA-N
InChiInChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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IPI-549 is a potent and selective phosphoinositide-3-kinase (PI3K) Inhibitor as an Immuno-Oncology Clinical Candidate (Kd = 0.29 nM). Bioactivity data of IPI-549: biochemcial IC50 (nM) for PI3K isoform: 3200 (); 3500 (); 16 (); and >8400 () respectively. Cellar IC50 (nM) of IPI549 for PI3K isoform: 250 (); 240 (); 1.6 (); and 180 () respectively. IPI-549 shows >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K- mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors.

 

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