IC261
Catalog No: 611914
CAS Number: 186611-52-9
Purity: 98%
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 M and for Cdk5 is 4.5 mM.
IC261 is a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 selectively inhibits CK1 compared to other protein kinases by an ATP-competitive mechanism.
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Chemical Information
| Name | IC261 |
|---|---|
| Iupac Chemical Name | IC261 |
| Synonyms | IC-261; SU-5607 |
| Molecular Formula | C18H17NO4 |
| Molecular Weight | 311.33 |
| Smile | COc1cc(c(c(c1)OC)/C=C/2\c3ccccc3NC2=O)OC |
| InChiKey | JBJYTZXCZDNOJW-JLHYYAGUSA-N |
| InChi | InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+ |
| CAS Number | 186611-52-9 |
| MDL | MFCD00118156 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
