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IACS-9439

Catalog No.: 20911
Cas No.: 2231259-57-5
Purity : 98% Min.

IACS-9439 is a potent, highly selective and orally bioavailable CSF1R inhibitor. IACS-9439 displayed the predicted potency boost, with single-digit nanomolar potency in the MNSF-60 cell phenotypical assay and possessed reasonable metabolic stability when incubated with human and rat microsomal preparations. 

For research use only. We do not sell to patients.

Chemical Information

NameIACS-9439
Iupac Chemical Name(1S,2S)-2-(7-chloro-4-methoxy-6-((2-(1-methyl-1H-pyrazol-4- ylamino)pyrimidin-4-yl)methoxy)benzo[d]thiazol-2-ylamino)cyclohexanol
SynonymsIACS-9439 ; IACS9439 ; IACS 9439
Molecular FormulaC23H26ClN7O3S
Molecular Weight516.02
SmileClC1=C(C=C(C=2N=C(SC21)N[C@@H]2[C@H](CCCC2)O)OC)OCC2=NC(=NC=C2)NC=2C=NN(C2)C
InChiKeyJYFJGEOXSQLPMB-HOTGVXAUSA-N
InChiInChI=1S/C23H26ClN7O3S/c1-31-11-14(10-26-31)28-22-25-8-7-13(27-22)12-34-17-9-18(33-2)20-21(19(17)24)35-23(30-20)29-15-5-3-4-6-16(15)32/h7-11,15-16,32H,3-6,12H2,1-2H3,(H,29,30)(H,25,27,28)/t15-,16-/m0/s1
CAS Number2231259-57-5
Related CAS2231259-57-5

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationLight tan foam solid
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

20911 - IACS-9439 | CAS 2231259-57-5

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