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HUHS015

Catalog No.: 16062902
Cas No.: 1453097-13-6
Purity : 98% by HPLC 
16062902 - HUHS015 | CAS 1453097-13-6

Catalog number : 16062902

CAS number : 1453097-13-6

Molecular Formula : C19H18N4O 

Molecular Weight : 318.37242 

Iupac Chemical Name : 4-benzyl-3-methyl-1-(5-methyl-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-5-ol 

Smile : C(C1=CC=CC=C1)C=1C(=NN(C1O)C1=NC2=C(N1)C=CC(=C2)C)C

InChiKey : LFEFEOLVKXXVGD-UHFFFAOYSA-N

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SynonymsHUHS 015;HUHS-015 
Molecular FormulaC19H18N4O 
Molecular Weight318.37242 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC(C1=CC=CC=C1)C=1C(=NN(C1O)C1=NC2=C(N1)C=CC(=C2)C)C
InChiKeyLFEFEOLVKXXVGD-UHFFFAOYSA-N
InChiInChI=1S/C19H18N4O/c1-12-8-9-16-17(10-12)21-19(20-16)23-18(24)15(13(2)22-23)11-14-6-4-3-5-7-14/h3-10,24H,11H2,1-2H3,(H,20,21)
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HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. As expected, continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.

 

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