HS-173
Catalog No: 161009001
CAS Number: 1276110-06-5
Purity: 98% by HPLC
HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1 and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.
For research use only. We do not sell to patients.
Chemical Information
| Name | HS-173 |
|---|---|
| Iupac Chemical Name | ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate |
| Synonyms | HS173; HS 173; HS-173. |
| Molecular Formula | C21H18N4O4S |
| Molecular Weight | 422.46 |
| Smile | C1(=CC=CC=C1)S(=O)(=O)NC=1C=C(C=NC1)C=1C=CC=2N(C1)C(=CN2)C(=O)OCC |
| InChiKey | SEKOTFCHZNXZMM-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3 |
| CAS Number | 1276110-06-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
