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HS-173

Catalog No.: 161009001
Cas No.: 1276110-06-5
Purity : 98% by HPLC 
161009001 - HS-173 | CAS 1276110-06-5

Catalog number : 161009001

CAS number : 1276110-06-5

Molecular Formula : C21H18N4O4S 

Molecular Weight : 422.46 

Iupac Chemical Name : ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate 

Smile : C1(=CC=CC=C1)S(=O)(=O)NC=1C=C(C=NC1)C=1C=CC=2N(C1)C(=CN2)C(=O)OCC

InChiKey : SEKOTFCHZNXZMM-UHFFFAOYSA-N

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SynonymsHS173; HS 173; HS-173. 
Molecular FormulaC21H18N4O4S 
Molecular Weight422.46 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC1(=CC=CC=C1)S(=O)(=O)NC=1C=C(C=NC1)C=1C=CC=2N(C1)C(=CN2)C(=O)OCC
InChiKeySEKOTFCHZNXZMM-UHFFFAOYSA-N
InChiInChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3
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HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1 and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients. 

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