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Catalog No.: 16062204
Cas No.: 586395-74-6
Purity : 98% by HPLC 
16062204 - HLCL-61 | CAS 586395-74-6

Catalog number : 16062204

CAS number : 586395-74-6

Molecular Formula : C23H25ClN2O 

Molecular Weight : 380.916 

Iupac Chemical Name : 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride 

Smile : Cl.C(C)N1C2=CC=CC=C2C=2C=C(C=CC12)CNCC1=C(C=CC=C1)OC


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SynonymsHLCL 61; HLCL-61. 
Molecular FormulaC23H25ClN2O 
Molecular Weight380.916 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
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 HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

586395-74-6 - Request Bulk Quote

586395-74-6 - Request Bulk Quote