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HLCL-61 HCl

Catalog No.: 16122819
Cas No.: 1158279-20-9
Purity : 98% 
16122819 - HLCL-61 HCl | CAS 1158279-20-9

Catalog number : 16122819

CAS number : 1158279-20-9

Molecular Formula : C23H25ClN2O 

Molecular Weight : 380.916 

Iupac Chemical Name : HLCL-61 HCl 

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SynonymsHLCL61; HLCL 61; HLCL-61 
Molecular FormulaC23H25ClN2O 
Molecular Weight380.916 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

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