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HA15

Catalog No.: 16122816
Cas No.: 1609402-14-3
Purity : 98% 
16122816 - HA15 | CAS 1609402-14-3

Catalog number : 16122816

CAS number : 1609402-14-3

Molecular Formula : C23H22N4O3S2 

Molecular Weight : 466.574 

Iupac Chemical Name : HA15 

Smile : CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O

InChiKey : LBSMEKVVMYSTIH-UHFFFAOYSA-N

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SynonymsHA-15; HA 15 
Molecular FormulaC23H22N4O3S2 
Molecular Weight466.574 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O
InChiKeyLBSMEKVVMYSTIH-UHFFFAOYSA-N
InChiInChI=1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
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HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. Transcriptomic, proteomic, and biochemical studies identified the chaperone BiP/GRP78/HSPA5 as the specific target of HA15 and demonstrated that the interaction increases ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. 

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