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H3B-6527

Catalog No.: 179822
Cas No.: 1702259-66-2
Purity : 98.0%
179822 - H3B-6527 | CAS 1702259-66-2

Catalog number : 179822

CAS number : 1702259-66-2

Molecular Formula : C29H34Cl2N8O4

Molecular Weight : 629.543

Iupac Chemical Name : N-{2-[(6-{[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}-4-pyrimidinyl)amino]-5-(4-ethyl-1-piperazinyl)phenyl}acrylamide

Smile : ClC1=C(C(=C(C=C1OC)OC)Cl)NC(=O)N(C1=CC(=NC=N1)NC1=C(C=C(C=C1)N1CCN(CC1)CC)NC(C=C)=O)C

InChiKey : MBWRLLRCTIYXDW-UHFFFAOYSA-N

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SynonymsH3B-6527; H3B 6527; H3B6527.
Molecular FormulaC29H34Cl2N8O4
Molecular Weight629.543
Appearanceoff-white solid
Purity98.0%
SolubilitySoluble in DMSO
Storage-20 ℃ for 3 years
Shipping ConditionShipped under ambient temperature
SmileClC1=C(C(=C(C=C1OC)OC)Cl)NC(=O)N(C1=CC(=NC=N1)NC1=C(C=C(C=C1)N1CCN(CC1)CC)NC(C=C)=O)C
InChiKeyMBWRLLRCTIYXDW-UHFFFAOYSA-N
InChiInChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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H3B-6527 is a potent and orally active FGFR4 inhibitor with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4.

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